Blood clots are clumps that occur when blood hardens from a liquid to a solid.
- A blood clot that forms inside one of your veins or arteries is called a thrombus. A thrombus may also form in your heart.
- A thrombus that breaks loose and travels from one location in the body to another is called an embolus.
A thrombus or embolus can partly or completely block the flow of blood in a blood vessel.
- A blockage in an artery may prevent oxygen from reaching the tissues in that area. This is called ischemia. If ischemia is not treated promptly, it can lead to tissue damage or death.
- A blockage in the vein will often cause fluid buildup and swelling.
Situations in which a blood clot is more likely to form in veins include:
- Being on long-term bed rest
- Sitting for long periods, such as in a plane or car
- During and after pregnancy
- Taking birth control pills or estrogen hormones (especially in women who smoke)
- Long-term use of an intravenous catheter
- After surgery
Blood clots are also more likely to form after an injury. People with cancer, obesity, and liver or kidney disease are also prone to blood clots.
Smoking also increases the risk of forming blood clots.
Conditions that are passed down through families (inherited) may make you more likely to form abnormal blood clots. Inherited conditions that affect clotting are:
- Factor V Leiden mutation
- Prothrombin G20210A mutation
Protein C, protein S
Congenital protein C or S deficiency is a lack of proteins C or S in the fluid part of the blood. The proteins are natural substances that help prev...Read Article Now Book Mark Article
Antithrombin III deficiencies
Congenital antithrombin III deficiency is a genetic disorder that causes the blood to clot more than normal.Read Article Now Book Mark Article
A blood clot may block an artery or vein in the heart, affecting the:
- Heart (angina or a heart attack)
- Intestines (mesenteric ischemia or mesenteric venous thrombosis)
Mesenteric artery ischemia occurs when there is a narrowing or blockage of one or more of the three major arteries that supply the small and large in...Read Article Now Book Mark Article
- Kidneys (renal vein thrombosis)
- Leg or arm arteries
- Legs (deep vein thrombosis)
- Lungs (pulmonary embolism)
- Neck or brain (stroke)
Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Anderson JA, Hogg KE, Weitz JI. Hypercoagulable states. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 140.
Schafer AI. Approach to the patient with bleeding and thrombosis: hypercoagulable states. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 162.