Bronchiectasis is a disease in which the large airways in the lungs are damaged. This causes the airways to become permanently wider.
Bronchiectasis can be present at birth or infancy or develop later in life.
Bronchiectasis is often caused by inflammation or infection of the airways that keeps coming back.
Sometimes it begins in childhood after having a severe lung infection or inhaling a foreign object. Breathing in food particles can also lead to this condition.
Inhaling a foreign object
If you swallow a foreign object, it can get stuck along the gastrointestinal (GI) tract from the esophagus (swallowing tube) to the colon (large inte...Read Article Now Book Mark Article
Other causes of bronchiectasis can include:
- Cystic fibrosis, a disease that causes thick, sticky mucus to build up in the lungs
- Autoimmune disorders, such as rheumatoid arthritis or Sjögren syndrome
- Allergic lung diseases
- Leukemia and related cancers
- Immune deficiency syndromes
- Primary ciliary dyskinesia (another congenital disease)
- Infection with non-tuberculous mycobacteria
Symptoms develop over time. They may occur months or years after the event that causes the bronchiectasis.
Long-term (chronic) cough with large amounts of foul smelling sputum is the main symptom of bronchiectasis. Other symptoms may include:
Exams and Tests
The health care provider will perform a physical exam. When listening to the chest with a stethoscope, the provider may hear small clicking, bubbling, wheezing, rattling, or other sounds, usually in the lower lungs.
Tests that may be done include:
- Aspergillosis precipitin test (to check for signs of an allergic reaction to fungus)
- Alpha-1 antitrypsin blood test
- Chest x-ray
- Chest CT
- Sputum culture
- Complete blood count (CBC)
- Genetic testing, including sweat test for cystic fibrosis and tests for other diseases (like primary ciliary dyskinesia)
- PPD skin test to check for a past tuberculosis infection
- Serum immunoglobulin electrophoresis to measure proteins called immunoglobulins in the blood
- Lung function tests to measure breathing and how well the lungs are functioning
- Immune deficiency workup
Treatment is aimed at:
- Controlling infections and sputum
- Relieving airway blockage
- Preventing the problem from becoming worse
Daily drainage to remove sputum is part of treatment. A respiratory therapist can show the person coughing exercises that will help.
Medicines are often prescribed. These include:
- Antibiotics to treat infections
- Bronchodilators to open up airways
- Expectorants to help loosen and cough up thick sputum
Surgery to remove (resect) the lung may be needed if medicine does not work and the disease is in a small area, or if the person has a lot of bleeding in the lungs. It is more commonly considered if there is no genetic or acquired predisposition to bronchiectasis (for example, more likely to consider if there is bronchiectasis in one segment of the lung only because of prior obstruction).
The outlook depends on the specific cause of the disease. With treatment, most people live without major disability and the disease progresses slowly.
Complications of bronchiectasis may include:
When to Contact a Medical Professional
Call your provider if:
- Chest pain or shortness of breath gets worse
- There is a change in the color or amount of phlegm you cough up, or if it is bloody
- Other symptoms get worse or do not improve with treatment
You can reduce your risk by promptly treating lung infections.
Childhood vaccines and a yearly flu vaccine help reduce the chance of some infections. Avoiding upper respiratory infections, smoking, and pollution may also reduce your risk of getting this infection.
Denis Hadjiliadis, MD, MHS, Paul F. Harron, Jr. Associate Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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