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5'-nucleotidase

Show Alternative Names
5'-NT

5'-nucleotidase (5'-NT) is a protein produced by the liver. A test can be done to measure the amount of this protein in your blood.

How the Test is Performed

Blood is drawn from a vein. You may feel slight pain or a sting when the needle is inserted. Afterward, there may be some throbbing.

How to Prepare for the Test

Your health care provider may tell you to stop taking some medicines that could interfere with the test. Drugs that may affect results include:

  • Acetaminophen (Tylenol)
  • Halothane
  • Isoniazid
  • Methyldopa
  • Nitrofurantoin

Why the Test is Performed

Your provider may order this test if you have signs of a liver problem. It is used mostly to tell if the high protein level is due to liver damage or skeletal muscle damage.

Normal Results

The normal value is 2 to 17 units per liter.

Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results.

The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.

What Abnormal Results Mean

Greater than normal levels may indicate:

  • Flow of bile from the liver is blocked (cholestasis)
  • Heart failure
  • Hepatitis (inflamed liver)
  • Lack of blood flow to the liver
  • Liver tissue death
  • Liver cancer or tumor
  • Lung disease
  • Ovarian cancer
  • Pancreas disease
  • Rheumatoid arthritis
  • Scarring of the liver (cirrhosis)
  • Use of drugs that are toxic to the liver

Risks

Slight risks from having blood drawn may include:

  • Excessive bleeding
  • Fainting or feeling lightheaded
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)
  • Bruising

Text only

Review Date: 1/24/2021

Reviewed By

David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

References

Pincus MR, Carty RP. Clinical enzymology. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 21.

Pratt DS. Liver chemistry and function tests. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 73.

Disclaimer

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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Blood test - Illustration Thumbnail

Blood test

Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.

Illustration

Blood test - Illustration Thumbnail

Blood test

Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.

Illustration

 
 
 
 

 

 
 

 
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